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Efegatran sulfate

NMR下載 COA and HPLC MSDS下載
names：
(S)-1-(N-((S)-5-guanidino-1-oxopentan-2-yl)-N-methyl-D-phenylalanyl)pyrrolidine-2-carboxamide sulfate
CAS號：
126721-07-1
MDL Number：
MF(分子式)： C21H34N6O7S MW(分子量)： 514.59
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Efegatran sulfate
英文別名	Efegatran sulfate; LY294468 sulfate; LY 294468 sulfate; LY-294468 sulfate;
CAS號	126721-07-1
Inchi	InChI=1S/C21H32N6O3.H2O4S/c1-26(16(14-28)9-5-11-25-21(23)24)18(13-15-7-3-2-4-8-15)20(30)27-12-6-10-17(27)19(22)29;1-5(2,3)4/h2-4,7-8,14,16-18H,5-6,9-13H2,1H3,(H2,22,29)(H4,23,24,25);(H2,1,2,3,4)/t16-,17-,18+;/m0./s1
InchiKey	VQRNSOAWJKHUJL-WSLRHHBVSA-N
分子式 Formula	C21H34N6O7S
分子量 Molecular Weight	514.59
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Efegatran sulfate(CAS:126721-07-1):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Efegatran sulfate is an antithrombotic.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Fung AY, Lorch G, Cambier PA, Hansen D, Titus BG, Martin JS, Lee JJ, Every NR, Hallstrom AP, Stock-Novack D, Scherer J, Weaver WD. Efegatran sulfate as an adjunct to streptokinase versus heparin as an adjunct to tissue plasminogen activator in patients with acute myocardial infarction. ESCALAT Investigators. Am Heart J. 1999 Oct;138(4 Pt 1):696-704. PubMed PMID: 10502216.

[2]PRIME Investigators. Multicenter, dose-ranging study of efegatran sulfate versus heparin with thrombolysis for acute myocardial infarction: The Promotion of Reperfusion in Myocardial Infarction Evolution (PRIME) trial. Am Heart J. 2002 Jan;143(1):95-105. PubMed PMID: 11773918.

[3] Lijnen HR. Efegatran. Institute for drug research/IVAX. IDrugs. 2001 Jun;4(6):691-4. PubMed PMID: 16001314.

[4] Klootwijk P, Lenderink T, Meij S, Boersma H, Melkert R, Umans VA, Stibbe J, Müller EJ, Poortermans KJ, Deckers JW, Simoons ML. Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina. Eur Heart J. 1999 Aug;20(15):1101-11. PubMed PMID: 10413640.

[5] Smith GF, Shuman RT, Craft TJ, Gifford DS, Kurz KD, Jones ND, Chirgadze N, Hermann RB, Coffman WJ, Sandusky GE, Roberts E, Jackson CV. A family of arginal thrombin inhibitors related to efegatran. Semin Thromb Hemost. 1996;22(2):173-83. PubMed PMID: 8807715.

6: Shetler TJ, Crowe VG, Bailey BD, Jackson CV. Antithrombotic assessment of the effects of combination therapy with the anticoagulants efegatran and heparin and the glycoprotein IIb-IIIa platelet receptor antagonist 7E3 in a canine model of coronary artery thrombosis. Circulation. 1996 Oct 1;94(7):1719-25. PubMed PMID: 8840866.7: Callas DD, Hoppensteadt D, Fareed J. Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog, and hirudin. Semin Thromb Hemost. 1995;21(2):177-83. PubMed PMID: 7660140.8: Sanderson PE, Naylor-Olsen AM. Thrombin inhibitor design. Curr Med Chem. 1998 Aug;5(4):289-304. Review. PubMed PMID: 9668196.9: Tarzami ST, Wang G, Li W, Green L, Singh JP. Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells. J Thromb Haemost. 2006 Mar;4(3):656-63. PubMed PMID: 16460448.10: Kaiser B, Koza M, Walenga JM, Fareed J. Flow cytometric evaluation of the effect of various thrombin inhibitors on platelet activation in whole blood. Thromb Res. 1996 May 1;82(3):257-63. PubMed PMID: 8732629.1

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